Boost Your Child’s Immune System | Homeopathic Immune Boosting

An equivalence trial was performed by Steinsbekk et al. (), who investigated whether individualized treatment by homeopaths is effective in preventing childhood upper respiratory tract infections (URTI). Children recruited from a group previously diagnosed with URTI, were randomly assigned to receive either homeopathic care or to conventional health care. There was a significant difference in median total symptom score in favor of homeopathic care compared to the control group. On the other hand, negative results were obtained by the same group () in a double-blind placebo-controlled randomized trial. Children with recurrent URTI were randomly assigned to receive either placebo or homeopathic medicines in 30c potency, chosen by parents using a simplified constitutional indications for the three medicines most frequently prescribed by Norwegian homeopaths for this group of patients (). When necessary, patients of both groups were allowed to take conventional medication. There was no difference in the predefined primary outcome between the two groups. This can be due to the lack of effect of the highly diluted homeopathic medicines, to the interference of conventional treatment, or the process of selection of medicines, that was performed by parents.

Complex Formulations

To cure one or few symptoms, particularly in short-lasting and acute conditions, complex formulations or mixtures of homeopathic remedies are often used. The complex homeopathy was born a little after the original discovery of Hahnemann and it is not fully comparable with homotoxicology which is a specific methodological way to prescribe complex homeopathic drugs. The latter procedure, also called ‘Biological medicine’, was developed in the second half of twentieth century (,), starting from Germany. Although homotoxicology is characterized by methods of diagnosis and prescription very different from Hahnemann’s original homeopathy, most of the formulations have their roots in the materia medica of single components and have the recognition of ‘homeopathic medicines’ by EU drug legislation.

Trials assessing the effectiveness of complex medicines in relieving specific symptoms are easier to be conducted as compared with those that require individualized treatment and continuous adjustment of therapy. Moreover, there is much higher commercial interest to such formulations than to single remedies, which cannot be patented. These reasons explain why there are relatively more studies of complex formulations than of single homeopathic remedies.

The primary objective of treating of inflammatory diseases of upper respiratory tract (rhinitis, uncomplicated sinusitis) is to relieve obstruction and to improve associated symptoms. In this respect, a homeopathic remedy may be seen much like a local decongestant helping restoration of unrestricted respiration and drainage of nasal sinuses, factors that reduce the risk of further complications and of chronicity. However, many homeopathic formulations contain remedies that are expected to act as immunostimulators and/or according to isopathic principles of cure.

A homeopathic remedy, L52, a complex formulation containing E. perfoliatum 3×, Aconitum napellus 4×, Bryonia alba 3×, Arnica montana 4×, Gelsemium sempervirens 6×, Cinchona 4×, Belladonna 4×, Drosera 3×, Senega 3× showed promising results, in a double-blind study against placebo, for relief of symptoms of URTI (), but not in prevention of flu in a large double-blind, placebo-controlled study (∼1200 participants) ().

In a single-blind randomized trial, army soldiers suffering from common cold were treated with aspirin or with a complex homeopathic preparation called Grippheel (Aconitum 4×, Bryonia 4×, Lachesis 12×, E. perfoliatum 3×, phosphorus 5×) (). Comparison between the changes in clinical status and in subjective disorders on days 4 and 10 and between the duration of the periods off work in two groups revealed no significant differences, leading to the conclusion that the two drugs are equieffective. More recently, the same medicine has been evaluated in a prospective, observational cohort study in patients affected by mild viral infections of upper respiratory tract () with encouraging results, consisting of an equivalent effectiveness of homeopathy and conventional medications.

In the field of respiratory diseases, mention must be made of a study by some French researchers () who treated dry cough with a syrup based on the plant Drosera and another nine substances in 3c dilution, and found that it was much better than placebo: after 1 week of therapy, the symptom had become less severe or had disappeared in 20 out of 30 treated patients, as against only 8 out of 30 in placebo group.

Euphorbium

Sprenger () conducted an open study of a low-dilution complex homeopathic preparation, Euphorbium compositum, used as a nasal spray in patients with acute or chronic rhinitis. The product consisted of Euphorbium resinifera 4×, Pulsatilla pratensis 2×, L. operculata 2×, Mercurius iodatus ruber 6×, Mucosa nasalis suis 6×, Hepar sulphuris calcareum 10×, Argentum nitricum 10× and Sinusitis nosode 13×, and was administered at a dose of 1–2 puffs per nostril 3–5 times a day. The physician’s judgment of the therapy was good in 83% of cases, whereas tolerability was excellent in 55.4% of cases and good in 44.6%. Another observational, uncontrolled study on patients suffering from chronic rhinopathy associated with a previous long-term application of medication (abuse of nasal spray) showed positive results in 22 out of 26 patients, with normalization of rhinomanometric tests ().

Subsequently, Weiser and Clasen () studied the clinical effectiveness of the same complex E. compositum in a double-blind, randomized, placebo-controlled study in subjects with chronic sinusitis. The treated group showed a significant improvement in terms of subjective symptoms such as respiratory obstruction, sensation of internal pressure and pain, but there was no substantial variation in instrumental tests. An overall evaluation showed a better improvement in verum group as in placebo group.

A further open, multicenter, prospective, active-controlled cohort study was carried out more recently on the homeopathic complex E. compositum (nasal drops), whose effectiveness and tolerability was compared with the reference allopathic drug xylometazoline (). Clinically relevant reductions in intensities of disease-specific symptoms were observed with both groups. Non-inferiority of the homeopathic complex remedy to xylometazoline could be shown for all studied variables. Tolerability was good for both therapies. Interestingly, it has been reported that some components of this medicine, e.g. Euphorbium and Pulsatilla, but not Luffa, as plant extract (not homeopathic preparations), have a direct antiviral (respiratory syncytial virus and herpes simplex virus type 1) effect in vitro ().

Other Low-Dilution Complexes

Zenner and Metelmann () published the results of an open study of a complex preparation, Lymphomyosot drops (Myosotis arvensis 3×, Veronica officinalis 3×, Teucrium scorodonia 3×, Pinus sylvestris 4×, and even other 13 plant or mineral components) in treatment of pharyngitis and tonsillitis. In a group of patients with tonsillitis, most of them recorded ‘excellent, good or satisfactory’ improvements after treatments lasting between 1 and 6 months.

A different complex that has been used in this kind of respiratory complaints is Engystol-N (made of Vincetoxicum 6×, 10× and 30×, sulfur 4× and 10×). A randomized, double-blind, placebo-controlled trial assessed the efficacy of this formulation, administered twice weekly as intravenous injection, for prophylaxis of common cold and flu (). The frequency of occurrence of flu or common cold was not changed by treatments, but the average length of illness and the severity of symptoms were less for the verum group than for the placebo group. No statistical analysis of data was provided.

The efficacy of three plants used in homeopathy to treat acute tonsillitis was evaluated with an open trial (). A fixed combination of low dilutions of three plant substances (Phytolacca americana, Guajacum officinale and Capsicum annuum) was used in patients with this condition and no antibiotics were used. According to materia medica, this homeopathic complex remedy should be characterized by immunomodulatory, analgesic and anti-inflammatory properties. A decrease in objective and subjective symptoms of acute tonsillitis symptoms was observed after treatment startup; no serious adverse effects were reported.

The efficacy and safety of a fixed combination homeopathic medication (Sinusitis PMD) consisting of Lobaria pulmonaria, L. operculata and potassium dichromate were investigated in an open-label practice-based study of patients with acute sinusitis (). Most patients received only test medication and no antibiotics. After 4 days of treatment, secretolysis had increased significantly and typical sinusitis symptoms, such as headache, pressure pain at nerve exit points and irritating cough, were reduced. The average treatment duration was 2 weeks. At the end of treatment, most patients described themselves as symptom-free or significantly improved. Adverse drug effects were not reported.

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